Potassium-competitive acid blockers: current clinical use and future developments

C Scarpignato, RH Hunt - Current Gastroenterology Reports, 2024 - Springer
Abstract Purpose of the Review Acid suppression with proton pump inhibitors (PPIs)
represents the standard of care in the treatment of acid-related diseases. However, despite …

AGA clinical practice update on integrating potassium-competitive acid blockers into clinical practice: expert review

A Patel, L Laine, P Moayyedi, J Wu - Gastroenterology, 2024 - Elsevier
Description The purpose of this American Gastroenterological Association (AGA) Institute
Clinical Practice Update (CPU) is to summarize the available evidence and offer expert Best …

Safety of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease

A Tietto, S Faggin, C Scarpignato… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Proton pump inhibitors (PPIs) are the first-line treatment for
gastroesophageal reflux disease (GERD). However, due to their intrinsic limitations, there …

The Effect of Dexlansoprazole on gastroesophageal reflux disease: a systematic review and Meta-analysis

GP Nunes, TC Silveira, JVS Marciano… - International Journal of …, 2024 - mdpi.com
This systematic review and meta-analysis evaluated the efficacy of dexlansoprazole (a
proton pump inhibitor—PPI) in resolving heartburn, reflux, and other symptoms and …

[HTML][HTML] Optimizing Helicobacter pylori Treatment: An Updated Review of Empirical and Susceptibility Test-Based Treatments

F Ishibashi, S Suzuki, M Nagai, K Mochida… - Gut and …, 2023 - ncbi.nlm.nih.gov
As the rate of discovery of drug-resistant Helicobacter pylori cases increases worldwide, the
relevant societies have updated their guidelines for primary eradication regimens. A …

Acid‐suppressive drugs: A systematic review and network meta‐analysis of their nocturnal acid‐inhibitory effect

S Zou, M Ouyang, Q Cheng, X Shi… - … : The Journal of Human …, 2024 - Wiley Online Library
Abstract Background and Aims Acid‐suppressive drugs (ASDs) are widely used in many
gastric acid‐associated diseases. Nocturnal acid breakthrough has been a common …

Potassium-competitive acid blockers and proton-pump inhibitors for healing of erosive esophagitis: a systematic review and network meta-analysis

Y Liu, Z Gao, XH Hou - Therapeutic Advances in …, 2024 - journals.sagepub.com
Background: Proton-pump inhibitors (PPIs) and potassium-competitive acid blockers (P-
CABs) are recommended for erosive esophagitis (EE), with good safety and tolerance …

Evaluating vonoprazan and tegoprazan for gastroesophageal reflux disease treatment in Chinese Healthcare: an EVIDEM framework analysis

C Xue, Y Du, H Yang, H Jin, Y Zhao, B Ren… - BMC Gastroenterology, 2024 - Springer
Abstract Background In Chinese healthcare settings, drug selection decisions are
predominantly influenced by the Pharmacy & Therapeutics Committee (PTC). This study …

Pharmacokinetic and pharmacodynamic exploration of various combinations of tegoprazan immediate and delayed‐release formulations

S Park, E Yang, B Kim, J Kwon… - British Journal of …, 2023 - Wiley Online Library
Aims The new modified‐release formulation of tegoprazan, a novel potassium‐competitive
acid blocker, is expected to improve the management of acid‐related disease, including …

Randomized, Double-blind, Active-controlled Phase 3 Study to Evaluate Efficacy and Safety of Zastaprazan compared to Esomeprazole in Erosive Esophagitis

JH Oh, HS Kim, DY Cheung, HL Lee… - Official journal of the …, 2022 - journals.lww.com
METHODS: A phase III, multicenter, randomized, double-blind, non-inferiority clinical study
was conducted with 300 subjects with confirmed EE. Subjects were randomized to receive …