The survival of spirochetes from the Borrelia burgdorferi (sensu lato) complex in a hostile
environment is achieved by the regulation of differential gene expression in response to …

Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …

The alternative sigma factor RpoS plays a central role in the critical host-adaptive response
of the Lyme disease spirochete, Borrelia burgdorferi. We previously identified bbd18 as a …

The RNA polymerase alternative σ factor RpoS in Borrelia burgdorferi (Bb), the Lyme
disease pathogen, is responsible for programmatic-positive and-negative gene regulation …

Lyme disease is a complex tick-borne zoonosis that poses an escalating public health threat
in several parts of the world, despite sophisticated healthcare infrastructure and decades of …

Borrelia burgdorferi, the Lyme disease spirochete, couples environmental sensing and gene
regulation primarily via the Hk1/Rrp1 two-component system (TCS) and Rrp2/RpoN/RpoS …

Borrelia burgdorferi, a pathogen transmitted by Ixodes ticks, is responsible for a prevalent
illness known as Lyme disease, and a vaccine for human use is unavailable. Recently …

The RpoS transcription factor of B orrelia burgdorferi is a 'gatekeeper'because it activates
genes required for spirochaetes to transition from tick to vertebrate hosts. However, it …

The bacterial pathogen Borrelia burgdorferi is the causative agent of Lyme disease and is
transmitted to humans through an Ixodes tick vector. B. burgdorferi is able to survive in both …