Current developments in LC-MS for pharmaceutical analysis

M Beccaria, D Cabooter - Analyst, 2020 - pubs.rsc.org
Liquid chromatography (LC) based techniques in combination with mass spectrometry (MS)
detection have had a large impact on the development of new pharmaceuticals in the past …

Miniaturized liquid chromatography focusing on analytical columns and mass spectrometry: A review

EVS Maciel, AL de Toffoli, E Sobieski, CED Nazário… - Analytica chimica …, 2020 - Elsevier
The technological advances achieved over the last decades boosted the development of
suitable benchtop platforms to work at miniaturized liquid chromatography scale (capillary …

The history of electron ionization in LC-MS, from the early days to modern technologies: A review

G Famiglini, P Palma, V Termopoli, A Cappiello - Analytica Chimica Acta, 2021 - Elsevier
This review article traces the history of the use of liquid chromatography coupled with mass
spectrometry (LC-MS) using electron ionization (EI) from the first attempts up to the present …

High-performance liquid chromatography combined with electron ionization mass spectrometry: A review

F Rigano, PQ Tranchida, P Dugo, L Mondello - TrAC Trends in Analytical …, 2019 - Elsevier
The present review illustrates the state of the art in the field of liquid chromatography (LC)
hyphenated to electron ionization mass spectrometry (EI MS). An overview of applications …

Aqueous naphthenic acids and polycyclic aromatic hydrocarbons in a meso-scale spill tank affected by diluted bitumen analyzed directly by membrane introduction …

J Monaghan, Q Xin, R Aplin, A Jaeger… - Journal of Hazardous …, 2022 - Elsevier
With the increasing use of unconventional, heavy crude oils there is growing interest in
potential impacts of a diluted bitumen (DB) spill in marine and freshwater environments. DB …

Miniaturization of liquid chromatography coupled to mass spectrometry.: 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled …

DAV Medina, EVS Maciel, AL de Toffoli… - TrAC Trends in Analytical …, 2020 - Elsevier
Capillary and nano liquid chromatography coupled to mass spectrometry has recently
become one of the primary analytical techniques in many science areas of maior interest …

Electron ionization mass spectrometry: Quo vadis?

EVS Maciel, NG Pereira dos Santos… - …, 2022 - Wiley Online Library
Mass spectrometry (MS) is a fundamental technique to identify compounds by their mass‐to‐
charge ratio. It is known that MS can only detect target compounds when they are converted …

An overview of open tubular liquid chromatography with a focus on the coupling with mass spectrometry for the analysis of small molecules

DAV Medina, NGP Dos Santos… - … of Chromatography A, 2021 - Elsevier
Open tubular liquid chromatography (OT-LC) can provide superior chromatographic
performance and more favorable mass spectrometry (MS) detection conditions. These …

Recent advances in mass spectrometry-based structural elucidation techniques

X Ma - Molecules, 2022 - mdpi.com
Mass spectrometry (MS) has become the central technique that is extensively used for the
analysis of molecular structures of unknown compounds in the gas phase. It manipulates the …

In situ organic biosignature detection techniques for space applications

V Abrahamsson, I Kanik - Frontiers in Astronomy and Space Sciences, 2022 - frontiersin.org
The search for life in Solar System bodies such as Mars and Ocean Worlds (eg, Europa and
Enceladus) is an ongoing and high-priority endeavor in space science, even∼ five decades …