Mitotic spindle assembly in animal cells: a fine balancing act
SL Prosser, L Pelletier - Nature Reviews Molecular Cell Biology, 2017 - nature.com
The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …
into the two daughter cells during cell division, which is paramount for maintaining genome …
Polo-like kinases: structural variations lead to multiple functions
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis
V Joukov, A De Nicolo - Science signaling, 2018 - science.org
Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …
Playing polo during mitosis: PLK1 takes the lead
Abstract Polo-like kinase 1 (PLK1), the prototypical member of the polo-like family of
serine/threonine kinases, is a pivotal regulator of mitosis and cytokinesis in eukaryotes …
serine/threonine kinases, is a pivotal regulator of mitosis and cytokinesis in eukaryotes …
Kinase and phosphatase cross-talk at the kinetochore
AT Saurin - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …
Maintaining transcriptional specificity through mitosis
Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …
The ins and outs of Aurora B inner centromere localization
S Hindriksen, SMA Lens, MA Hadders - Frontiers in cell and …, 2017 - frontiersin.org
Error-free chromosome segregation is essential for the maintenance of genomic integrity
during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger …
during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger …
[HTML][HTML] Plk1 and Mps1 cooperatively regulate the spindle assembly checkpoint in human cells
C von Schubert, F Cubizolles, JM Bracher, T Sliedrecht… - Cell reports, 2015 - cell.com
Equal mitotic chromosome segregation is critical for genome integrity and is monitored by
the spindle assembly checkpoint (SAC). We have previously shown that the consensus …
the spindle assembly checkpoint (SAC). We have previously shown that the consensus …
Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1
In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …
CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization
D Hayward, T Alfonso-Pérez, MJ Cundell… - Journal of Cell …, 2019 - rupress.org
Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached
kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase …
kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase …