The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Abstract Polo-like kinase 1 (PLK1), the prototypical member of the polo-like family of
serine/threonine kinases, is a pivotal regulator of mitosis and cytokinesis in eukaryotes …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

Error-free chromosome segregation is essential for the maintenance of genomic integrity
during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger …

Equal mitotic chromosome segregation is critical for genome integrity and is monitored by
the spindle assembly checkpoint (SAC). We have previously shown that the consensus …

In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐
kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle …

Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached
kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase …