Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

Living organisms enantioselectively employ L-amino acids as the molecular architecture of
protein synthesized in the ribosome. Although L-amino acids are dominantly utilized in most …

The endogenous NMDA receptor (NMDAR) agonist d-aspartate occurs transiently in the
mammalian brain because it is abundant during embryonic and perinatal phases before …

It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a
crucial role in several N-methyl d-aspartate receptor-mediated physiological and …

Besides d-serine, another d-amino acid with endogenous occurrence in the mammalian
brain, d-aspartate, has been recently shown to influence NMDA receptor (NMDAR) …

D-aspartate levels in the brain are regulated by the catabolic enzyme D-aspartate oxidase
(DDO). D-aspartate activates NMDA receptors, and influences brain connectivity and …

In recent years, the D-enantiomers of amino acids have been recognized as natural
molecules present in all kingdoms, playing a variety of biological roles. In humans, d-serine …

Abstract d-Amino acids are the" wrong" enantiomers of amino acids as they are not used in
proteins synthesis but evolved in selected functions. On this side, d-aspartate (d-Asp) plays …

Drug resistance remains to be a serious problem with type I human immunodeficiency virus
(HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic …

Free d-aspartate is abundant in the mammalian embryonic brain. However, following the
postnatal onset of the catabolic d-aspartate oxidase (DDO) activity, cerebral d-aspartate …