[HTML][HTML] The TNF family of ligands and receptors: communication modules in the immune system and beyond
C Dostert, M Grusdat, E Letellier… - Physiological …, 2018 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
Structural principles of tumor necrosis factor superfamily signaling
ÉS Vanamee, DL Faustman - Science signaling, 2018 - science.org
The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …
TNFα and the TNF receptor superfamily: Structure‐function relationship (s)
HT Idriss, JH Naismith - Microscopy research and technique, 2000 - Wiley Online Library
Abstract Tumour Necrosis Factor α (TNFα), is an inflammatory cytokine produced by
macrophages/monocytes during acute inflammation and is responsible for a diverse range …
macrophages/monocytes during acute inflammation and is responsible for a diverse range …
TRAIL and apoptosis induction by TNF-family death receptors
S Wang, WS El-Deiry - Oncogene, 2003 - nature.com
Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a
member of the tumor necrosis factor (TNF) family of ligands capable of initiating apoptosis …
member of the tumor necrosis factor (TNF) family of ligands capable of initiating apoptosis …
The molecular architecture of the TNF superfamily
JL Bodmer, P Schneider, J Tschopp - Trends in biochemical sciences, 2002 - cell.com
Ligands of the TNF (tumour necrosis factor) superfamily have pivotal roles in the
organization and function of the immune system, and are implicated in the aetiology of …
organization and function of the immune system, and are implicated in the aetiology of …
Promoting apoptosis as a strategy for cancer drug discovery
SW Fesik - Nature Reviews Cancer, 2005 - nature.com
Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that
restore the normal apoptotic pathways have the potential for effectively treating cancers that …
restore the normal apoptotic pathways have the potential for effectively treating cancers that …
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
FC Kischkel, DA Lawrence, A Chuntharapai, P Schow… - Immunity, 2000 - cell.com
Abstract Fas (APO-1/CD95) and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis
by recruiting the apoptosis initiator caspase-8 through the adaptor FADD. Fas binds FADD …
by recruiting the apoptosis initiator caspase-8 through the adaptor FADD. Fas binds FADD …
IL-17: prototype member of an emerging cytokine family
S Aggarwal, AL Gurney - Journal of leukocyte biology, 2002 - academic.oup.com
IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The large-
scale sequencing of the human and other vertebrate genomes has revealed the presence of …
scale sequencing of the human and other vertebrate genomes has revealed the presence of …
Apo2L/TRAIL and its death and decoy receptors
HN LeBlanc, A Ashkenazi - Cell Death & Differentiation, 2003 - nature.com
Apo2 ligand or tumour necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …
The methionine-aromatic motif plays a unique role in stabilizing protein structure
Of the 20 amino acids, the precise function of methionine (Met) remains among the least well
understood. To establish a determining characteristic of methionine that fundamentally …
understood. To establish a determining characteristic of methionine that fundamentally …