Myocardial interstitial fibrosis contributes to left ventricular dysfunction leading to the
development of heart failure. Basic research has provided abundant evidence for the …

Marfan syndrome (MFS) is a systemic connective tissue disorder that is inherited in an
autosomal dominant pattern with variable penetrance. While clinically this disease manifests …

Purpose Marfan syndrome (MFS) is a connective tissue disorder in which several systems
are affected with great phenotypic variability. Although known to be associated with …

The manufacture of fibrous scaffolds with tailored micrometric features and anatomically
relevant three-dimensional (3D) geometries for soft tissue engineering applications remains …

Marfan syndrome (MFS) is an autosomal dominant, age-related but highly penetrant
condition with substantial intrafamilial and interfamilial variability. MFS is caused by …

The Ross, or pulmonary autograft, procedure presents a fascinating mechanobiological
scenario. Due to the common embryological origin of the aortic and pulmonary root, the …

Background and objectives In personalised external aortic root support (PEARS), a custom-
made, macroporous mesh is used to stabilise a dilated aortic root and prevent dissection …

Additive Manufacturing is noted for ease of product customization and short production run
cost-effectiveness. As our global population approaches 8 billion, additive manufacturing …

Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in
the fibrillin-1 gene. Acute aortic dissection is the leading cause of death in patients suffering …

Cardiac surgeries may expose pulmonary arterial tissue to systemic conditions, potentially
resulting in failure of that tissue. Our goal was to quantitatively assess pulmonary artery …