The members of the Management and Therapy Subcommittee undertook an evidence-
based review of current dry eye therapies and management options. Management options …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

Many factors in the domains of mental, physical, and social health have been associated
with various ocular surface diseases, with most of the focus centered on aspects of dry eye …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

A key element of contact lens practice involves clinical evaluation of anterior eye health,
including the cornea and limbus, conjunctiva and sclera, eyelids and eyelashes, lacrimal …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

Background Dry eye disease (DED) is a multifactorial disease associated with ocular
surface inflammation, pain, and nerve abnormalities. We studied the peripheral and central …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

Purpose To describe the association between Sars-CoV-2 infection and small fiber
neuropathy in the cornea identified by in vivo corneal confocal microscopy. Methods Twenty …