Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation …

Over a century ago, colloidal phase separation of matter into non-membranous bodies was
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

How remote enhancers interact with appropriate target genes persists as a central mystery
in gene regulation. Here, we exploit the properties of transvection to explore enhancer …

Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal
expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle …

The ten-eleven translocation (TET) proteins play a crucial role in promoting locus-specific
reversal of DNA methylation, a type of chromatin modification. Considerable evidences have …

In previous work, we showed that intrinsically disordered regions (IDRs) of proteins contain
sequence-distributed molecular features that are conserved over evolution, despite little …

Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in
transcription factors. Tract length often correlates with transcriptional activity and expansion …

Lactic acid is a platform chemical for the sustainable production of various materials. To
develop a robust yeast platform for low‐pH production of d‐lactic acid (LA), an acid‐tolerant …