Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …

Background: The heart grows in response to pathological and physiological stimuli. The
former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …

Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Background—A variety of studies carried out using either human subjects or laboratory
animals suggest that vitamin D and its analogues possess important beneficial activity in the …

The heart responds to injury and chronic pressure overload by pathologic growth and
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …