Evaluating the polarization of tumor-associated macrophages into M1 and M2 phenotypes in human cancer tissue: technicalities and challenges in routine clinical …

SD Jayasingam, M Citartan, TH Thang… - Frontiers in …, 2020 - frontiersin.org
Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment
have gained much interests as basic science regarding their roles in tumor progression …

Macrophage polarization in THP-1 cell line and primary monocytes: A systematic review

ZNM Yasin, FNM Idrus, CH Hoe, GB Yvonne-Tee - Differentiation, 2022 - Elsevier
Macrophages derived from human monocytic leukemia THP-1 cell line are often used as the
alternative of human primary macrophage. However, the polarization method of THP-1 to …

Little to no expression of angiotensin‐converting enzyme‐2 on most human peripheral blood immune cells but highly expressed on tissue macrophages

X Song, W Hu, H Yu, L Zhao, Y Zhao, X Zhao… - Cytometry Part …, 2023 - Wiley Online Library
Abstract Angiotensin‐converting enzyme‐2 (ACE2) has been recognized as the binding
receptor for the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Flow …

Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation

RD Kirkton, M Santiago-Maysonet, JH Lawson… - Science translational …, 2019 - science.org
Traditional vascular grafts constructed from synthetic polymers or cadaveric human or
animal tissues support the clinical need for readily available blood vessels, but often come …

Wnt signaling modulates macrophage polarization and is regulated by biomaterial surface properties

JO Abaricia, AH Shah, M Chaubal, KM Hotchkiss… - Biomaterials, 2020 - Elsevier
Macrophages are among the first cells to interact with biomaterials and ultimately determine
their integrative fate. Biomaterial surface characteristics like roughness and hydrophilicity …

Molecular aspects and future perspectives of cytokine-based anti-cancer immunotherapy

DS Chulpanova, KV Kitaeva, AR Green… - Frontiers in cell and …, 2020 - frontiersin.org
Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines,
as proteins of the immune system, are able to modulate the host immune response toward …

[HTML][HTML] Tumor vessel co-option probed by single-cell analysis

LA Teuwen, LPMH De Rooij, A Cuypers, K Rohlenova… - Cell reports, 2021 - cell.com
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-
angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and …

Effect of platelet-rich plasma on M1/M2 macrophage polarization

R Uchiyama, E Toyoda, M Maehara, S Wasai… - International journal of …, 2021 - mdpi.com
Osteoarthritis of the knee (OAK) is a chronic degenerative disease and progresses with an
imbalance of cytokines and macrophages in the joint. Studies regarding the use of platelet …

Exosomal CD47 plays an essential role in immune evasion in ovarian cancer

A Shimizu, K Sawada, M Kobayashi… - Molecular Cancer …, 2021 - AACR
Ovarian cancer is largely diagnosed at advanced stages upon detection of multiple
peritoneal dissemination, resulting in poor outcomes. CD47 is overexpressed in tumors …

Soft tissue features of peri‐implant diseases and related treatment

ME Galarraga‐Vinueza, L Tavelli - Clinical implant dentistry …, 2023 - Wiley Online Library
Background The need for soft tissue grafting at implant sites for preventing and treating peri‐
implant diseases is a currently investigated and debated topic. Purpose The aim of this …