Metabolomics meets systems immunology

J Fu, F Zhu, CJ Xu, Y Li - EMBO reports, 2023 - embopress.org
Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …

Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Precise metabolomics reveals a diversity of aging‐associated metabolic features

H Tian, Z Ni, SM Lam, W Jiang, F Li, J Du… - Small …, 2022 - Wiley Online Library
Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …

Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer

H Wang, H Jia, Y Gao, H Zhang, J Fan, L Zhang… - Nature …, 2022 - nature.com
Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients
with locally advanced rectal cancer (LARC). Therapeutic efficacy of nCRT is significantly …

Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Y Liu, J Jiang, S Du, L Mu, J Fan, J Hu, Y Ye, M Ding… - Science, 2024 - science.org
Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of
reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries …

Increasing diversity of functional genetics studies to advance biological discovery and human health

SHL George, A Medina-Rivera, Y Idaghdour… - The American Journal of …, 2023 - cell.com
In this perspective we discuss the current lack of genetic and environmental diversity in
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …

Deciphering the Plasmodium falciparum perinuclear var gene expression site

G Diffendall, A Scherf - Trends in Parasitology, 2024 - cell.com
The protozoan parasite Plasmodium falciparum, responsible for the deadliest form of human
malaria, employs antigenic variation via monoallelic expression as a key survival strategy …

Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees

Z Cen, B Lu, Y Ji, J Chen, Y Liu, J Jiang, X Li, X Li - Talanta, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) vaccines can protect people from the
infection; however, the action mechanism of vaccine-mediated metabolism remains unclear …

Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses

X Hu, J Zhao, J Zhao, E Yang, M Jia - Parasites & Vectors, 2023 - Springer
Background The liver is responsible for a range of functions in vertebrates, such as
metabolism and immunity. In malaria, the liver plays a crucial role in the interaction between …

Advances in integrative African genomics

C Zhang, MEB Hansen, SA Tishkoff - Trends in Genetics, 2022 - cell.com
There has been a rapid increase in human genome sequencing in the past two decades,
resulting in the identification of millions of previously unknown genetic variants. However …