Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …
Precise metabolomics reveals a diversity of aging‐associated metabolic features
Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …
biomedical research, although technical issues with its analytical precision and structural …
Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer
H Wang, H Jia, Y Gao, H Zhang, J Fan, L Zhang… - Nature …, 2022 - nature.com
Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients
with locally advanced rectal cancer (LARC). Therapeutic efficacy of nCRT is significantly …
with locally advanced rectal cancer (LARC). Therapeutic efficacy of nCRT is significantly …
Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction
Y Liu, J Jiang, S Du, L Mu, J Fan, J Hu, Y Ye, M Ding… - Science, 2024 - science.org
Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of
reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries …
reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries …
Increasing diversity of functional genetics studies to advance biological discovery and human health
In this perspective we discuss the current lack of genetic and environmental diversity in
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …
Deciphering the Plasmodium falciparum perinuclear var gene expression site
G Diffendall, A Scherf - Trends in Parasitology, 2024 - cell.com
The protozoan parasite Plasmodium falciparum, responsible for the deadliest form of human
malaria, employs antigenic variation via monoallelic expression as a key survival strategy …
malaria, employs antigenic variation via monoallelic expression as a key survival strategy …
Virus-induced breath biomarkers: A new perspective to study the metabolic responses of COVID-19 vaccinees
Abstract Coronavirus disease 2019 (COVID-19) vaccines can protect people from the
infection; however, the action mechanism of vaccine-mediated metabolism remains unclear …
infection; however, the action mechanism of vaccine-mediated metabolism remains unclear …
Genome-wide liver transcriptomic profiling of a malaria mouse model reveals disturbed immune and metabolic responses
X Hu, J Zhao, J Zhao, E Yang, M Jia - Parasites & Vectors, 2023 - Springer
Background The liver is responsible for a range of functions in vertebrates, such as
metabolism and immunity. In malaria, the liver plays a crucial role in the interaction between …
metabolism and immunity. In malaria, the liver plays a crucial role in the interaction between …
Advances in integrative African genomics
There has been a rapid increase in human genome sequencing in the past two decades,
resulting in the identification of millions of previously unknown genetic variants. However …
resulting in the identification of millions of previously unknown genetic variants. However …