Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …

Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD.
These individuals experience greater pulmonary oxidative stress and inflammation, which …

Background Emerging evidence suggests that aging affects asthma outcomes, but the
mechanism remains largely unexplored. Objective To explore age-related clinical …

Several classes of antibiotics have long been known to have beneficial effects that cannot
be explained strictly on the basis of their capacity to control the infectious agent. Here, we …

The hypothalamic–pituitary–adrenal axis is a dynamic system regulating glucocorticoid
hormone synthesis in the adrenal glands. Many key factors within the adrenal steroidogenic …

Corticosteroids (CSs) are commonly used to manage wheezing and asthma in pediatric
populations. Although corticosteroids are effective in alleviating airway diseases, some …

Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases
including asthma and chronic obstructive pulmonary disease (COPD). However, it has been …

Asthma in elderly populations is an increasing health problem that is accompanied by
diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs …

LB-100 is an experimental cancer therapeutic with cytotoxic activity against cancer cells in
culture and antitumor activity in animals. The first phase I trial (NCT01837667) evaluating LB …

Although most patients with asthma symptoms are well controlled by inhaled glucocorticoids
(GCs), a subgroup of patients suffering from severe asthma respond poorly to GC therapy …