Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Spatial metabolomics principles and application to cancer research

M Planque, S Igelmann, AMF Campos… - Current Opinion in …, 2023 - Elsevier
Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …

Highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers in tissues

G Yagnik, Z Liu, KJ Rothschild… - Journal of the American …, 2021 - ACS Publications
Immunohistochemistry (IHC) combined with fluorescence microscopy provides an important
and widely used tool for researchers and pathologists to image multiple biomarkers in tissue …

[HTML][HTML] MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues

MJ Lim, G Yagnik, C Henkel, SF Frost, T Bien… - Frontiers in …, 2023 - frontiersin.org
Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is one
of the most widely used methods for imaging the spatial distribution of unlabeled small …

Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical Proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

MSIGen: an open-source python package for processing and visualizing mass spectrometry imaging data

E Hernly, H Hu, J Laskin - Journal of the American Society for …, 2024 - ACS Publications
Mass spectrometry imaging (MSI) provides information about the spatial localization of
molecules in complex samples with high sensitivity and molecular selectivity. Although point …

A Galaxy of informatics resources for MS-based proteomics

S Mehta, M Bernt, M Chambers, M Fahrner… - Expert Review of …, 2023 - Taylor & Francis
Introduction Continuous advances in mass spectrometry (MS) technologies have enabled
deeper and more reproducible proteome characterization and a better understanding of …

Cancer tissue classification using supervised machine learning applied to MALDI mass spectrometry imaging

P Mittal, MR Condina, M Klingler-Hoffmann, G Kaur… - Cancers, 2021 - mdpi.com
Simple Summary Classic histopathological examination of tissues remains the mainstay for
cancer diagnosis and staging. However, in some cases histopathologic analysis yields …

State-of-the-art mass spectrometry imaging applications in biomedical research

KK Krestensen, RMA Heeren, B Balluff - Analyst, 2023 - pubs.rsc.org
Mass spectrometry imaging has advanced from a niche technique to a widely applied spatial
biology tool operating at the forefront of numerous fields, most notably making a significant …

MALDI-MSI analysis of cancer drugs: Significance, advances, and applications

Q He, C Sun, J Liu, Y Pan - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …