The culture of Chinese Hamster Ovary (CHO) cells for modern industrial applications, such
as expression of recombinant proteins, requires media that support growth and production …

Cell-based therapies have the potential to make a large contribution toward currently unmet
patient need and thus effective manufacture of these products is essential. Many challenges …

As more and more cell and gene therapies are being developed and with the increasing
number of regulatory approvals being obtained, there is an emerging and pressing need for …

Background Human induced pluripotent stem cells (hiPSCs) hold enormous promise in
accelerating breakthroughs in understanding human development, drug screening, disease …

The use of hMSCs for allogeneic therapies requiring lot sizes of billions of cells will
necessitate large-scale culture techniques such as the expansion of cells on microcarriers in …

Accelerating the scale up of adeno-associated virus (AAV) manufacture is highly desirable
to meet the increased demand for gene therapies. However, the development of …

Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is
a delicate task, frequently leading to different conditions across scales. To provide a more …

Decreasing the timeframe for cell culture process development has been a key goal toward
accelerating biopharmaceutical development. Advanced Microscale Bioreactors (ambr™) is …

With recent advances in digitisation and big data analytics, more pharmaceutical firms are
adopting digital tools to achieve modernisation. The biological phenomena within …

In our recent work in different bioreactors up to 2.5 L in scale, we have successfully cultured
hMSCs using the minimum agitator speed required for complete microcarrier suspension, N …