The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for
tissue regeneration and remodeling due to their potent bioactivity, which includes …

Lysine acetylation is a conserved, reversible, post-translational protein modification
regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair
response disorder when organs undergo continuous damage, ultimately leading to scar …

Fibrosis usually results from dysregulated wound repair and is characterized by excessive
scar tissue. It is a complex process with unclear mechanisms. Accumulating evidence …

Fibroblasts are the major cell population in the connective tissue of most organs, where they
are essential for their structural integrity. They are best known for their role in remodelling …

Background Metabolic syndrome and related metabolic disturbances represent a state of
low-grade inflammation, which accelerates insulin resistance, type 2 diabetes (T2D) and …

Rationale: Pulmonary hypertensive remodeling is characterized by excessive proliferation,
migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts …

Reversible protein acetylation provides a central mechanism for controlling gene expression
and cellular signaling events. Two pharmacological inhibitors of protein deacetylation are …