Structure and applications of PIC-based polymers and hydrogels

K Liu, J Vandaele, H Yuan, KG Blank… - Cell Reports Physical …, 2024 - cell.com
Over the last decade, water-soluble polyisocyanopeptides (PICs) have emerged as a new
class of biomimetic polymers. Analogous to biopolymers, PICs exhibit a semi-flexible nature; …

[HTML][HTML] Injectable polyisocyanide hydrogel as healing supplement for connective tissue regeneration in an abdominal wound model

AN Gudde, MJJ van Velthoven, PHJ Kouwer… - Biomaterials, 2023 - Elsevier
In pelvic organ prolapse (POP) patients, the uterus, bladder and/or rectum descends into
vagina due to weakened support tissues. High recurrence rates after POP surgery suggest …

Reassessing human MHC-I genetic diversity in T cell studies

RC Slieker, DO Warmerdam, MH Vermeer… - Scientific reports, 2024 - nature.com
Abstract The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in
immune responses by presenting antigens to T cells. Allele specific technologies, including …

Monitoring Cell Proliferation by Dye Dilution: Considerations for Panel Design

JD Tario Jr, KT Soh, PK Wallace, KA Muirhead - Flow Cytometry Protocols, 2024 - Springer
High dimensional studies that include proliferation dyes face two inherent challenges in
panel design. First, the more rounds of cell division to be monitored based on dye dilution …

Emerging approaches for T cell-stimulating platform development

E Ariail, NG Espinoza, AC Stephenson, JB Spangler - Cell Systems, 2024 - cell.com
T cells are key mediators of the adaptive immune response, playing both direct and
supporting roles in the destruction of foreign pathogenic threats as well as pathologically …

[HTML][HTML] Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

L Weiss, M Schluck, R Classens, PKJD de Jonge… - Acta Biomaterialia, 2024 - Elsevier
Immunotherapies are a powerful strategy to treat cancer by modulating the immune system
to raise an anti-tumor immune response. A prime example of immunotherapies are cytokines …

Immunofilaments Are Well Tolerated after Local or Systemic Administration in Mice

L Weiss, R Classens, M Schluck, E Grad… - ACS Pharmacology & …, 2024 - ACS Publications
The invention of nanosized biomaterials has paved the way for novel therapeutics that can
manipulate cells on a nanoscale. Nanosized immunofilaments (IFs) are synthetic …

Nanomaterial‐Based Strategies for Preventing Tumor Metastasis by Interrupting the Metastatic Biological Processes

Q Cai, Y He, Y Zhou, J Zheng… - Advanced Healthcare …, 2024 - Wiley Online Library
Tumor metastasis is the primary cause of cancer‐related deaths. The prevention of tumor
metastasis has garnered notable interest and interrupting metastatic biological processes is …

The DC–T cell axis is an effective target for the treatment of non‐small cell lung cancer

S Wang, G Zhang, Q Cui, Y Yang… - Immunity …, 2023 - Wiley Online Library
The dendritic cell (DC)‐T cell axis is a bridge that connects innate and adaptive immunities.
The initial immune response against tumors is mainly induced by mature antigen‐presenting …

Crosstalking with dendritic cells: a path to engineer advanced T Cell immunotherapy

S Schafer, K Chen, L Ma - Frontiers in Systems Biology, 2024 - frontiersin.org
Crosstalk between dendritic cells and T cells plays a crucial role in modulating immune
responses in natural and pathological conditions. DC-T cell crosstalk is achieved through …