Over the last few years, conventional medicine has been increasingly moving towards
precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is …

Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve …

Pharmacometric methods have hugely benefited from progress in analytical and computer
sciences during the past decades, and play nowadays a central role in the clinical …

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) of unknown etiology, probably
caused by a combination of genetic and environmental factors. The treatment of patients …

Many important drugs exhibit substantial variability in pharmacokinetics and
pharmacodynamics leading to a loss of the desired clinical outcomes or significant adverse …

Standard‐of‐care infliximab dosing regimens were developed prior to the routine use of
therapeutic drug monitoring and identification of target concentrations. Not surprisingly …

Background Model-informed precision dosing (MIPD) can serve as a powerful tool during
therapeutic drug monitoring (TDM) to help individualize dosing in populations with large …

Genomics has helped to initiate the era of precision medicine, with some drugs now
prescribed on the basis of molecular genetic tests that indicate which patients are likely to …

Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …

Drug approval is based on exposure, response, and variability of studied populations,
typically excluding comorbidities/medications and very ill patients, thus not representing …