Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

The endoplasmic reticulum represents the gateway to the secretory pathway. Here, proteins
destined for secretion, as well as soluble and membrane proteins that reside in the …

Cleavable endoplasmic reticulum (ER) signal peptides (SPs) and other non-cleavable
signal sequences target roughly a quarter of the human proteome to the ER. These short …

Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

Most secreted and membrane proteins are targeted to and translocated across the
endoplasmic reticulum (ER) membrane through the Sec61 protein-conducting channel …

Mammalian membrane proteins perform essential physiologic functions that rely on their
accurate insertion and folding at the endoplasmic reticulum (ER). Using forward and arrayed …

In human cells, approximately 30% of all polypeptides enter the secretory pathway at the
level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal …

N‐linked protein glycosylation is a conserved and essential modification mediating protein
processing and quality control in the endoplasmic reticulum (ER), but how this contributes to …

Dual topologies of proteins at the ER membrane are known for a variety of proteins allowing
the same protein to exert different functions according to the topology adopted. A dual …

The endoplasmic reticulum (ER) of mammalian cells is the central organelle for the
maturation and folding of transmembrane proteins and for proteins destined to be secreted …