Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer …
AM Scherbakov, SK Vorontsova, AI Khamidullina… - Investigational New …, 2023 - Springer
The promising antitumor effects of progesterone derivatives have been identified in many
studies. However, the specific mechanism of action of this class of compounds has not been …
studies. However, the specific mechanism of action of this class of compounds has not been …
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold
A novel class of SARS-CoV-2 main protease (Mpro) inhibitors derived from 1, 5, 6, 7-
tetrahydro-4 H-indazol-4-ones was designed. Virtual screening based on molecular docking …
tetrahydro-4 H-indazol-4-ones was designed. Virtual screening based on molecular docking …
Design, Synthesis and Anti‐Tumor Activity Evaluation of Novel 3, 4‐(Methylenedioxy) cinnamic Acid Amide‐Dithiocarbamate Derivatives
J Guo, M Cheng, P Liu, D Cao, J Luo… - Chemistry & …, 2022 - Wiley Online Library
Abstract The fragments, 3, 4‐(methylenedioxy) cinnamic acid amide and dithiocarbamates,
have received increasing attention because of their multiple pharmacological activities in …
have received increasing attention because of their multiple pharmacological activities in …
1,2,3-Triazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones and 6,7-Dihydrobenzo[d]isoxazol-4(5H)-ones: Synthesis and Biological Activity
Abstract Triazole-containing 1, 5, 6, 7-tetrahydro-4 H-indazol-4-ones and 6, 7-dihydrobenzo
[d] isoxazol-4 (5 H)-ones were synthesized by cyclocondensation of 2-[(1 H-1, 2, 3-triazol-1 …
[d] isoxazol-4 (5 H)-ones were synthesized by cyclocondensation of 2-[(1 H-1, 2, 3-triazol-1 …