MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen,
the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 …

Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

Ample data indicate that mutant p53 proteins not only lose their tumour suppressive
functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies …

Rationale: Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal
development, which significantly limits the capacity of the adult mammalian heart to …

The control of cell proliferation by microRNAs (miRNAs) is well established and the
alteration of these small, non-coding RNAs may contribute to tumor development by …

During tumour development cells sustain mutations that disrupt normal mechanisms
controlling proliferation. Remarkably, the Rb–E2f and MDM2–p53 pathways are both …

The main physiological actions of the biologically most active metabolite of vitamin D, 1α, 25-
dihydroxyvitamin D3 (1α, 25 (OH) 2D3), are calcium and phosphorus uptake and transport …

Recent evidence supports a role for microRNAs (miRNAs) in regulating the life span of
model organisms. However, little is known about how these small RNAs contribute to human …