Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Background Cholestatic liver diseases can be caused by genetic defects, drug toxicities,
hepatobiliary malignancies or obstruction of the biliary tract. Cholestasis leads to …

Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …

Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and
cellular conditions. The mechanistic details of how a cell chooses among these cell fates are …

Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells
from solid tumours together with their native microenvironment. They offer a low throughput …

Bile acids (BAs) are cholesterol derivatives synthesized in the liver and then secreted into
the intestine for lipid absorption. There are numerous scientific reports describing BAs …

Background Brucea javanica (L.) Merr. is a plant from the genus Brucea, which is used in
local traditional medicine to treat various diseases. Recent studies revealed an impressive …

The transcription factors NF-κB and p53 as well as their crosstalk determine the fate of tumor
cells upon therapeutic interventions. Replicative stress and cytokines promote signaling …

Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the
controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR …