The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …

Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain
tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due
to its regulation of plasma low-density lipoprotein cholesterol (LDL-C) and its causal role in …

Introduction The association between ischemic stroke and genetic polymorphisms of
methylenetetrahydrofolate reductase (MTHFR; 677C> T and 1298A> C), endothelial nitric …

Proprotein convertase subtilisin/kexin type‐9 (PCSK9), a member of the proprotein
convertase family, is an important drug target because of its crucial role in lipid metabolism …

Background and aims Genetic studies have been reported on the association between
APOA5, APOB, APOC3 and ABCA1 gene polymorphisms and ischemic stroke, but results …

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a scavenger receptor of
oxidized low-density lipoprotein (ox-LDL) found in various cells, plays a crucial role in the …

Atherosclerosis is one of the major causes of cerebral infarction and many other ischemic
cardio-cerebrovascular diseases. Although large randomized clinical trials have highlighted …