The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial
Advancements in mass spectrometry‐based proteomics have enabled experiments
encompassing hundreds of samples. While these large sample sets deliver much‐needed …
encompassing hundreds of samples. While these large sample sets deliver much‐needed …
Missing data and technical variability in single-cell RNA-sequencing experiments
Until recently, high-throughput gene expression technology, such as RNA-Sequencing
(RNA-seq) required hundreds of thousands of cells to produce reliable measurements …
(RNA-seq) required hundreds of thousands of cells to produce reliable measurements …
Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
Tackling the widespread and critical impact of batch effects in high-throughput data
High-throughput technologies are widely used, for example to assay genetic variants, gene
and protein expression, and epigenetic modifications. One often overlooked complication …
and protein expression, and epigenetic modifications. One often overlooked complication …
Svaseq: removing batch effects and other unwanted noise from sequencing data
JT Leek - Nucleic acids research, 2014 - academic.oup.com
It is now known that unwanted noise and unmodeled artifacts such as batch effects can
dramatically reduce the accuracy of statistical inference in genomic experiments. These …
dramatically reduce the accuracy of statistical inference in genomic experiments. These …
Heritability and genomics of gene expression in peripheral blood
We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify
expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly …
expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly …
Recommendations for the design and analysis of epigenome-wide association studies
KB Michels, AM Binder, S Dedeurwaerder… - Nature …, 2013 - nature.com
Epigenome-wide association studies (EWAS) hold promise for the detection of new
regulatory mechanisms that may be susceptible to modification by environmental and …
regulatory mechanisms that may be susceptible to modification by environmental and …
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
Mapping complex disease traits with global gene expression
Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …
complex disease. The simultaneous genome-wide assay of gene expression and genetic …