Pancreatic cancer (PC) has the greatest mortality rate of all the main malignancies. Its
advanced stage and poor prognosis place it at the bottom of all cancer sites. Hence …

Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor
diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic …

Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach
in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is …

Cancer is a significant challenge for effective treatment due to its complex mechanism,
different progressing stages, and lack of adequate procedures for screening and …

Abstract Background Cancer stem cells (CSCs) play an important role in the development of
pancreatic cancer. We previously showed that the microRNA miR-137 is downregulated in …

Cancer is one of the leading causes of death worldwide. Breast cancer is the second
leading cause of death in women, with triple‐negative breast cancer being the most lethal …

Targeting of genomic quadruplexes is an approach to treating complex human cancers. We
describe a series of tetra-substituted naphthalene diimide (ND) derivatives with a phenyl …

Recently, fibroblast growth factors are identified to play a vital role in the development and
progression of human pancreatic cancer. FGF pathway is critical involved in numerous …

Methods: This research was performed on newly diagnosed breast cancer patients referred
to Omid Radiotherapy Center and radiotherapy and oncology departments of Emam Reza …

The development of drug-resistance by neoplastic cells is recognized as a major cause of
targeted therapy failure and disease progression. The mechanistic (previously mammalian) …