Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

Adipose tissue plays an important role in systemic metabolism via the secretion of
adipocytokines and storing and releasing energy. In obesity, adipose tissue becomes …

Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In
rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in …

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

The obesity epidemic has led researchers and clinicians to reconsider the etiology of this
disease and precisely decipher its molecular mechanisms. The excessive accumulation of …

Interactions between macrophages and adipocytes influence both metabolism and
inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic …