A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

The β-thalassemia syndromes reflect deficient or absent β-globin synthesis usually owing to
a mutation in the β-globin locus. The relative excess of α-globin results in the formation of …

Excessive iron has emerged in a large population of patients suffering from degenerative or
hematological diseases with a common outcome, osteoporosis. However, its underlying …

Erythropoietin (EPO) stimulates proliferation of early-stage erythrocyte precursors and is
widely used for the treatment of chronic anemia. However, several types of EPO-resistant …

Inherited anemias with ineffective erythropoiesis, such as β-thalassemia, manifest
inappropriately low hepcidin production and consequent excessive absorption of dietary …

Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via
increased erythropoietin (EPO) synthesis in kidney and liver. Hepcidin, a small polypeptide …

The erythroblastic island (EBI), composed of a central macrophage and surrounding
erythroid cells, was the first hematopoietic niche discovered. The identity of EBI …

Hepcidin agonists are a new class of compounds that regulate blood iron levels, limit iron
absorption, and could improve the treatment of hemochromatosis, β-thalassemia …

Regulation of erythropoiesis is achieved by the integration of distinct signals. Among them,
macrophages are emerging as erythropoietin-complementary regulators of erythroid …

The definition 'iron loading anaemias' encompasses a group of inherited and acquired
anaemias characterized by ineffective erythropoiesis, low hepcidin levels, excessive iron …