Abstract Purpose of Review The development of acute to chronic pain involves distinct
pathophysiological changes in the peripheral and central nervous systems. This article …

Prevention of Opioid Overdose This review explains harm-reduction strategies for three
groups of patients: those who have not received previous opioid therapy, those receiving …

Aim To understand the potential harmful effects of dose escalation among patients with
chronic, noncancer pain (CNCP) on chronic opioid therapy. Design Retrospective cohort …

Prescribers are often confronted with the decision to escalate opioid doses to achieve
adequate analgesia. Understanding the impact of dose escalation on pain intensity is …

Patients frequently come to the emergency department for pain. For decades, ketamine has
been used in the emergency department for procedural sedation but is now receiving …

Study Design: This was a retrospective cohort study. Objective: Investigate the impact of
preoperative opioid use on postoperative Patient-Reported Outcomes Measurement …

Chronic postsurgical pain is a common surgical complication that severely reduces a
patient's quality of life. Many perioperative interventions and management strategies have …

Purpose This study compared the effects of Benson relaxation with progressive muscle
relaxation on pain severity after laminectomy. Design Three-arm randomized, nonblinded …

Remifentanil, ultra-short-acting μ-opioid receptor agonist, has the greatest advantage in
analgesia but could increase postoperative pain scores and induces postoperative …

Placebo and nocebo effects have been well documented for nearly two centuries. However,
research has only relatively recently begun to explicate the neurobiological underpinnings …