The science underlying COVID-19: implications for the cardiovascular system
The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy
worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those …
worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those …
DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation
Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …
breakthroughs. However, many inflammatory pathologies remain without specific therapy …
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is
appreciated that different tissues instruct specialized macrophage functions. However …
appreciated that different tissues instruct specialized macrophage functions. However …
Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair
WP Lafuse, DJ Wozniak, MVS Rajaram - Cells, 2020 - mdpi.com
The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …
inflammation following insult or damage to organs. The heart is a vital organ which supplies …
Cardioimmunology: the immune system in cardiac homeostasis and disease
FK Swirski, M Nahrendorf - Nature Reviews Immunology, 2018 - nature.com
The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …
an important contribution to cardiac development, composition and function. Immune cells …
Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …
An acute immune response underlies the benefit of cardiac stem cell therapy
Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …
Stress and inflammation in coronary artery disease: a review psychoneuroendocrineimmunology-based
Recent findings have deeply changed the current view of coronary heart disease, going
beyond the simplistic model of atherosclerosis as a passive process involving cholesterol …
beyond the simplistic model of atherosclerosis as a passive process involving cholesterol …
A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair
K Sun, Y Li, J Jin - Signal transduction and targeted therapy, 2021 - nature.com
The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …
The extracellular matrix protein agrin promotes heart regeneration in mice
E Bassat, YE Mutlak, A Genzelinakh, IY Shadrin… - Nature, 2017 - nature.com
The adult mammalian heart is non-regenerative owing to the post-mitotic nature of
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …