Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin …

As we approach the end of two decades of leptin research, the comparative biology of leptin
is just beginning. We now have several leptin orthologs described from nearly every major …

Background Body weight (BW) is an economically important trait in the broiler (meat-type
chickens) industry. Under the assumption of polygenicity, a “large” number of genes with …

Genetic selection that has been carried out for several dozen years has led to significant
progress in poultry production by improving productive traits and increasing the profitability …

Over a decade passed between Friedman's discovery of the mammalian leptin gene and its
cloning in fish and amphibians. Since 2005, the concept of gene synteny conservation (vs …

Broiler breeder hens grow more efficiently and are leaner than ever before due to positive
results from broiler genetic selection strategies. Quantitative feed restriction is used to limit …

Billions of birds migrate long distances to either reach breeding areas or to spend the winter
at more benign places. On migration, most passerines frequently stop over to rest and …

In mammals, leptin is an important energy homeostasis hormone produced by adipose
tissue. Circulating leptin concentrations correlate positively with fat mass and act in a …

Chickens are remarkably versatile animals that are used as model organisms for biomedical
research. Here, we performed metabolomic and RNA sequencing (RNA-Seq) transcriptomic …

Leptin is a cytokine-like hormone that regulates food intake and energy homeostasis via its
interaction with the leptin receptor (LEPR) located in the target tissues. Leptindependent …