Bovine leukemia virus: a major silent threat to proper immune responses in cattle

MC Frie, PM Coussens - Veterinary immunology and immunopathology, 2015 - Elsevier
Bovine leukemia virus (BLV) infection is widespread in the US dairy industry and the
majority of producers do not actively try to manage or reduce BLV incidence within their …

Host immune responses in the course of bovine leukemia virus infection

H KABEYA, K OHASHI, M ONUMA - Journal of Veterinary Medical …, 2001 - jstage.jst.go.jp
Bovine leukemia virus (BLV) is a type C retrovirus infecting bovine B cells and causing
enzootic bovine leukosis. Since it takes long periods to develop the disease, it is believed …

The rapid quantitative analysis of bovine cytokine genes by real-time RT-PCR

S Konnai, T Usui, K Ohashi, M Onuma - Veterinary microbiology, 2003 - Elsevier
For a practical need, fast and efficient methods to quantify mRNA expression are expecting.
By using real-time reverse transcription polymerase chain reaction (RT-PCR) with the …

Bovine leukemia virus: current perspectives

MA Juliarena, CN Barrios… - Virus adaptation and …, 2017 - Taylor & Francis
Enzootic bovine leukosis, caused by bovine leukemia virus (BLV), is the most common
neoplasm of dairy cattle. Although beef and dairy cattle are susceptible to BLV infection and …

Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade

R Ikebuchi, S Konnai, T Shirai, Y Sunden, S Murata… - Veterinary …, 2011 - Springer
The inhibitory receptor programmed death-1 (PD-1) and its ligand, programmed death-
ligand 1 (PD-L1) are involved in immune evasion mechanisms for several pathogens …

Toll-like receptors, IFN-γ and IL-12 expression in bovine leukemia virus-infected animals with low or high proviral load

MVN Farias, PA Lendez, M Marin, S Quintana… - Research in veterinary …, 2016 - Elsevier
Bovine leukemia virus (BLV) infection is widespread mainly in dairy cattle and 5–10% of
infected animals will die due to lymphosarcoma; most cattle remain asymptomatic but 30 …

The role, relevance and management of immune exhaustion in bovine infectious diseases

S Sharma, N Kumar, BT Rouse, K Sharma… - Heliyon, 2024 - cell.com
Immune exhaustion is a state of immune cell dysfunction that occurs most commonly
following chronic exposure to an antigen which persists after the immune response fails to …

Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection

T Okagawa, S Konnai, A Nishimori, N Maekawa… - Veterinary …, 2018 - Springer
Bovine leukemia virus (BLV) is a retrovirus that infects B cells in cattle and causes bovine
leukosis after a long latent period. Progressive exhaustion of T cell functions is considered to …

[HTML][HTML] Imbalance of tumor necrosis factor receptors during progression in bovine leukemia virus infection

S Konnai, T Usui, M Ikeda, J Kohara, T Hirata, K Okada… - Virology, 2005 - Elsevier
Previously, we found an up-regulation of tumor necrosis factor alpha (TNF)-α and an
imbalance of TNF receptors in sheep experimentally infected with bovine leukemia virus …

The Global Epidemiology of Bovine Leukemia Virus: Current Trends and Future Implications

G Lv, J Wang, S Lian, H Wang, R Wu - Animals, 2024 - mdpi.com
Simple Summary Bovine leukemia virus (BLV) is the causative agent of enzootic bovine
leukosis (EBL), which is the most significant neoplastic disease in cattle. EBL is often …