Transcription by RNA polymerase III (pol III) is responsible for~ 15% of total cellular
transcription through the generation of small structured RNAs such as tRNA and 5S RNA …

RNA polymerase III transcribes small untranslated RNAs that fulfill essential cellular
functions in regulating transcription, RNA processing, translation and protein translocation …

The target of rapamycin complex 1 (TORC1) is an essential multiprotein complex conserved
from yeast to humans. Under favorable growth conditions, and in the absence of the …

Abstract mTORC1 is a central regulator of growth in response to nutrient availability, but few
direct targets have been identified. RNA polymerase (pol) III produces a number of essential …

Summary RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under
stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We …

We report genome-wide analyses that establish Maf1 as a general and direct repressor of
yeast RNA polymerase (Pol) III transcription. Chromatin immunoprecipitation (ChIP) coupled …

Maf1 is an essential and specific mediator of transcriptional repression in the RNA
polymerase (pol) III system. Maf1-dependent repression occurs in response to a wide range …

Nutrient deprivation and various stress conditions repress RNA polymerase III (Pol III)
transcription in S. cerevisiae. The signaling pathways that relay stress and nutrient …

In Saccharomyces cerevisiae, Maf1 is essential for mediating the repression of transcription
by RNA polymerase (pol) III in response to diverse cellular conditions. These conditions …

Target of rapamycin (TOR)-dependent signaling and the control of cell growth is deregulated
in many cancers. However, the signaling molecules downstream of TOR that coordinately …