Population growth followed by rapid development of industrialisation has caused serious
environmental pollution with contaminants of emerging concern found in wastewater and …

This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …

The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a
drug has been released can lead to a severe restriction in its use and even in its withdrawal …

The occurrence of human and veterinary pharmaceuticals in the environment has been a
subject of concern for the past decade because many of these emerging contaminants have …

The nonsteroidal antiinflammatory drug diclofenac causes rare but significant cases of
serious hepatotoxicity, typically with a delayed onset (> 1–3 months). Because there is no …

Rare adverse reactions to drugs that are of unknown etiology, or idiosyncratic reactions, can
produce severe medical complications or even death in patients. Current hypotheses …

Protein covalent binding by xenobiotic metabolites has long been associated with target
organ toxicity but mechanistic involvement of such binding has not been widely …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with idiosyncratic
hepatotoxicity in susceptible patients. The molecular mechanisms underlying this toxicity …

Although glucuronidation is generally considered a detoxification route of drug metabolism,
the chemical reactivity of acyl glucuronides has been linked with the toxic properties of drugs …

Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is widely used for the
treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute muscle …