Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Obesity is a complex disease that affects whole body metabolism and is associated with an
increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Physical …

Transmission electron microscopy (TEM) is widely used as an imaging modality to provide
high-resolution details of subcellular components within cells and tissues. Mitochondria and …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Mitochondrial morphology varies tremendously across cell types and tissues, changing
rapidly in response to external insults and metabolic cues, such as nutrient status. The many …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions will only
increase. To help in combating the devastating array of phenotypes associated with T2DM a …