World population growth and aging are posing unprecedented challenges in sustaining the
health of 9.1 billion people that will be occupying the planet by 2050. Although …

Coenzyme Q10 (CoQ10) is an essential cofactor in oxidative phosphorylation (OXPHOS),
present in mitochondria and cell membranes in reduced and oxidized forms. Acting as an …

The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant
activity, and an increase in oxidative stress, marked by an increase in reactive oxygen …

Oxidative stress is a key component in carcinogenesis. Although radiation produces reactive
oxygen species, some anticancer agents such as alkylating agents, platinum and antitumor …

Background Interferon alpha is the only agent approved for the postoperative adjuvant
treatment of high‐risk cutaneous melanoma. However, the survival advantage associated …

Importance of the field: Coenzyme Q10 (CoQ10) is found in blood and in all organs. CoQ10
deficiencies are due to autosomal recessive mutations, ageing-related oxidative stress and …

Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of
the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was …

Reactive oxygen and nitrogen species (RONS), eg generated by cold physical plasma
(CPP) or photodynamic therapy, interfere with redox signaling pathways of mammalian cells …

An extensive number of pathologies are associated with mitochondrial dysfunction (MDF)
and oxidative stress (OS). Thus, mitochondrial cofactors termed “mitochondrial …

The generation of energy within cells is a fundamental process enabling cell survival, and as
such it represents a potential target in cancer therapy. In this article, we therefore review the …