Can essential oils provide an alternative adjuvant therapy for COVID-19 infections and pain management at the same time?

R Damiescu, DYW Lee, T Efferth - Pharmaceuticals, 2022 - mdpi.com
The active compounds from essential oils have been an important asset in treating different
diseases for many centuries. Nowadays, there are various available formulations used as …

Inflammatory biomarkers in addictive disorders

A Morcuende, F Navarrete, E Nieto, J Manzanares… - Biomolecules, 2021 - mdpi.com
Substance use disorders are a group of diseases that are associated with social,
professional, and family impairment and that represent a high socio-economic impact on the …

Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: the role of CREB/BDNF and …

S Keshavarzi, S Kermanshahi, L Karami… - Neurotoxicology, 2019 - Elsevier
Background Methamphetamine is a neuro-stimulant with neurodegenerative effects, and
ambiguous mechanism of action. Metformin is an antidiabetic agent with neuroprotective …

The neuroprotective effect of curcumin against nicotine-induced neurotoxicity is mediated by CREB–BDNF signaling pathway

M Motaghinejad, M Motevalian, S Fatima… - Neurochemical …, 2017 - Springer
Nicotine abuse adversely affects brain and causes apoptotic neurodegeneration. Curcumin-
a bright yellow chemical compound found in turmeric is associated with neuroprotective …

Molecular characterisation of the mechanism of action of stimulant drugs lisdexamfetamine and methylphenidate on ADHD neurobiology: a review

J Quintero, JR Gutiérrez-Casares, C Álamo - Neurology and therapy, 2022 - Springer
Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset
neurodevelopmental disorder characterised by persistent inattention, hyperactivity and …

Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme

G Sharma, EJ Shin, N Sharma, SY Nah, HN Mai… - Food and Chemical …, 2021 - Elsevier
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its
own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a …

Morphine addiction and oxidative stress: The potential effects of thioredoxin-1

XS Zeng, WS Geng, ZQ Wang, JJ Jia - Frontiers in pharmacology, 2020 - frontiersin.org
Long-term administration of morphine for the management of chronic pain will result in
tolerance to its analgesic effect and could even cause drug dependence. Numerous studies …

Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats

M Motaghinejad, M Motevalian, S Fatima… - Biomedicine & …, 2017 - Elsevier
Background Alcohol abuse causes severe damage to the brain neurons. Studies have
reported the neuroprotective effects of curcumin against alcohol-induced …

Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats

M Motaghinejad, M Motevalian, B Shabab - Neuroscience letters, 2016 - Elsevier
Methylphenidate (MPH) is a central stimulant, prescribed for the treatment of attention
deficit/hyperactivity disorder. The long-term behavioral consequences of MPH treatment are …

Zebrafish models relevant to studying central opioid and endocannabinoid systems

KA Demin, DA Meshalkina, EV Kysil… - Progress in neuro …, 2018 - Elsevier
The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that
modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although …