The ribosome is a structurally and functionally conserved macromolecular machine
universally responsible for catalyzing protein synthesis. Within eukaryotic cells, mitochondria …

Bacterial ribosome biogenesis has been an active area of research for more than 30 years
and has served as a test-bed for the development of new biochemical, biophysical and …

The ribosome is a complex macromolecular machine and serves as an ideal system for
understanding biological macromolecular assembly. Direct observation of ribosome …

The stringent response is a survival mechanism used by bacteria to deal with stress. It is
coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p) ppGpp] …

During assembly, ribosomal particles in bacteria fold according to energy landscapes
comprised of multiple parallel pathways. Cryo-electron microscopy studies have identified a …

Bacteria harbor a number GTPases that function in the assembly of the ribosome and are
essential for growth. RbgA is one of these GTPases and is required for the assembly of the …

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize 13 proteins, essential
components of the oxidative phosphorylation system. They are linked to mitochondrial …

While small molecule inhibitors of the bacterial ribosome have been instrumental in
understanding protein translation, no such probes exist to study ribosome biogenesis. We …

Abstract YphC and YsxC are GTPases in Bacillus subtilis that facilitate the assembly of the
50S ribosomal subunit, however their roles in this process are still uncharacterized. To …

The formation of chloroplasts can be traced back to an ancient event in which a eukaryotic
host cell containing mitochondria ingested a cyanobacterium. Since then, chloroplasts have …