Autophagy is a cellular process that removes damaged components of cells and recycles
them as biochemical building blocks. Autophagy can also be induced to protect cells in …

Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The
identification of kinases controlling these processes has direct therapeutic implications. We …

Protein kinases, one of the largest enzyme superfamilies, regulate many physiological and
pathological processes. They are drug targets for multiple human diseases, including …

Macroautophagy/autophagy is a tightly regulated catabolic process, which contributes at
baseline level to cellular homeostasis, and upon its stimulation to the adaptive cellular …

Genome-wide association studies identified variants around the BIN1 (bridging integrator 1)
gene locus as prominent risk factors for late-onset Alzheimer disease. In the present study …

The genome of human papillomaviruses (HPVs) encodes the E1 replication factor, whose
biological activities are regulated by cellular protein kinases. Here, the phosphorylation …

Cutaneous human papillomavirus type 5 (HPV5) belongs to the supposedly oncogenic β-
HPVs associated with specific types of skin and oral cavity cancers. Three viral proteins …

This thesis examines the role of autophosphorylation and Microtubule Interacting and
Trafficking (MIT) domains on Unc-51 like kinase 3 (ULK3) kinase activity. ULK3 is a …

Aberrant cytosine methylation is one of the most common alterations in cancer, with global
hypomethylation and regional hypermethylation characterizing many different malignancies …

Autophagy is a conserved catabolic pathway triggered by stress conditions in which portions
of the cytoplasm, damage organelles, misfolded proteins and intracellular bacteria are …