[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

The implication of 5-HT receptor family members in aggression, depression and suicide: similarity and difference

NK Popova, AS Tsybko, VS Naumenko - International journal of molecular …, 2022 - mdpi.com
Being different multifactorial forms of psychopathology, aggression, depression and suicidal
behavior, which is considered to be violent aggression directed against the self, have …

A unique inflammation-related mechanism by which high-fat diets induce depression-like behaviors in mice

H Yu, B Yu, X Qin, W Shan - Journal of affective disorders, 2023 - Elsevier
Background High-fat diet (HFD) consumption is an important reason for promoting
depression, but the mechanism is unclear. The present study aims to explore the …

Psychological mechanisms and functions of 5-HT and SSRIs in potential therapeutic change: Lessons from the serotonergic modulation of action selection, learning …

C Roberts, BJ Sahakian, TW Robbins - Neuroscience & biobehavioral …, 2020 - Elsevier
Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

PR Albert, B Le François, F Vahid-Ansari - Journal of psychiatry and …, 2019 - jpn.ca
Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

[HTML][HTML] Biased agonism in drug discovery: Is there a future for biased 5-HT1A receptor agonists in the treatment of neuropsychiatric diseases?

K Sałaciak, K Pytka - Pharmacology & Therapeutics, 2021 - Elsevier
Abstract Serotonin (5-HT) is one of the fundamental neurotransmitters that contribute to the
information essential for an organism's normal, physiological function. Serotonin acts …

5-HT receptors and temperature homeostasis

IP Voronova - Biomolecules, 2021 - mdpi.com
The present review summarizes the data concerning the influence of serotonin (5-HT)
receptors on body temperature in warm-blooded animals and on processes associated with …

[HTML][HTML] Overcoming resistance to selective serotonin reuptake inhibitors: targeting serotonin, serotonin-1A receptors and adult neuroplasticity

F Vahid-Ansari, M Zhang, A Zahrai… - Frontiers in …, 2019 - frontiersin.org
Major depressive disorder (MDD) is the most prevalent mental illness contributing to global
disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line …

Modulation of the serotonergic receptosome in the treatment of anxiety and depression: a narrative review of the experimental evidence

GR Villas-Boas, SN Lavorato, MM Paes… - Pharmaceuticals, 2021 - mdpi.com
Serotonin (5-HT) receptors are found throughout central and peripheral nervous systems,
mainly in brain regions involved in the neurobiology of anxiety and depression. 5-HT …

[HTML][HTML] Serotonin receptor and transporter endocytosis is an important factor in the cellular basis of depression and anxiety

N Deo, G Redpath - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Depression and anxiety are common, debilitating psychiatric conditions affecting millions of
people throughout the world. Current treatments revolve around selective serotonin …