In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …

The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new
area of research that has led to the discovery of several life-saving antimicrobial agents …

Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

Decoquinate (DQ) has low oral bioavailability owing to its poor water solubility. In this study,
a DQ solid dispersion (DQ-SD) was fabricated using mechanochemical technology to …

The quinolone decoquinate is coadministered with feed for treatment of parasites which
cause coccidiosis in poultry. However, from a drug-development perspective, the biological …

The emergence of resistance toward artemisinin combination therapies (ACTs) by the
malaria parasite Plasmodium falciparum has the potential to severely compromise malaria …

Vesicles are widely investigated as carrier systems for active pharmaceutical ingredients
(APIs). For topical delivery, they are especially effective since they create a “depot-effect” …

The emergence of Plasmodium falciparum (Pf) parasite strains tolerant of the artemisinin
component and resistant to the other drug component in artemisinin combination therapies …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), still remains one of the
leading causes of death from a single infectious agent worldwide. The high prevalence of …

Tuberculosis (TB) is currently the leading cause of mortality due to an infectious disease,
despite the existence of multiple effective first-line and second-line drugs. The current anti …