Malignant melanoma is notorious for its inter-and intratumour heterogeneity, based on
transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct …

Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable
tumour control and result in the long-term survival of patients with advanced cancers …

Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded
remarkable response rates and many durable responses in clinical trials in melanoma; …

Melanoma is characterised by its ability to metastasise at early stages of tumour
development. Current clinico‐pathologic staging based on the American Joint Committee on …

Purpose: The development of a genetic signature for the identification of high-risk cutaneous
melanoma tumors would provide a valuable prognostic tool with value for stage I and II …

Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous
type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory …

Background Wnt proteins are important for developmental processes and certain diseases.
WNT5A is a non-canonical Wnt protein that previously has been shown to play a role in the …

Melanoma is currently divided on a genetic level according to mutational status. However,
this classification does not optimally predict prognosis. In prior studies, we have defined …

Recent studies revealed trajectories of mutational events in early melanomagenesis, but the
accompanying changes in gene expression are far less understood. Therefore, we …