Oxidative stress and inflammation have been recognized as important contributors to the risk
of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate …

One of the most controversial areas of nutrition research relates to fats, particularly essential
fatty acids, in the context of cardiovascular disease risk. A critical feature of dietary fatty acids …

Aims Despite the effects of statins in reducing cardiovascular events and slowing
progression of coronary atherosclerosis, significant cardiovascular (CV) risk remains …

Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …

Background: The effect of alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type
9) inhibitor, on coronary plaque burden in patients with familial hypercholesterolemia has …

Background REDUCE-IT was a double-blind trial that randomized 8,179 statin-treated
patients with controlled low-density lipoprotein cholesterol and moderately elevated …

Mineral oil is often used as a clinical trial placebo. Pharmaceutical-grade mineral oil consists
of a mixture of saturated hydrocarbons, with a purity and chemical structure that differs …

An important advantage of computed tomography coronary angiography (CCTA) is its ability
to visualize the presence and severity of atherosclerotic plaque, rather than just assessing …

Background: Patients with elevated triglycerides despite statin therapy have increased risk
for ischemic events, including coronary revascularizations. Methods: REDUCE-IT (The …

Fish oil is rich in unsaturated fatty acids, ie, eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), both of which are widely distributed in the body such as heart …