Destruction and detection of chemical warfare agents

K Kim, OG Tsay, DA Atwood, DG Churchill - Chemical reviews, 2011 - ACS Publications
This review is shaped in scope by much and various chemical, biological, materials science,
device, and chemical engineering literature. This review is intended to make major …

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… <? ACS-CT-START-Insert?> Jang<? ACS-CT … - Chemical …, 2015 - ACS Publications
Yang and co-workers appeared (Figure 1), 2 and 16 years since their accompanying
Accounts article,“Chemical Detoxification of Nerve Agent VX.” 14 Also, organophosphonate …

[HTML][HTML] The role of oximes in the management of organophosphorus pesticide poisoning

P Eyer - Toxicological reviews, 2003 - Springer
The number of intoxications with organophosphorus pesticides (OPs) is estimated at some 3
000 000 per year, and the number of deaths and casualties some 300 000 per year. OPs act …

Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes

F Worek, H Thiermann, L Szinicz, P Eyer - Biochemical pharmacology, 2004 - Elsevier
The wide-spread use of organophosphorus compounds (OP) as pesticides and the
availability of highly toxic OP-type chemical warfare agents (nerve agents) underlines the …

[HTML][HTML] Organophosphorus compounds as chemical warfare agents: a review

RT Delfino, TS Ribeiro… - Journal of the Brazilian …, 2009 - SciELO Brasil
Chemical warfare agents constitute one of the greatest threats in the modern world. Among
them, the neurotoxic agents are of special interest due to their high lethality and danger …

Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase

A Saxena, AMG Redman, X Jiang, O Lockridge… - Biochemistry, 1997 - ACS Publications
Amino acid sequence alignments of cholinesterases revealed that 6 of 14 aromatic amino
acid residues lining the active center gorge of acetylcholinesterase are replaced by aliphatic …

The value of novel oximes for treatment of poisoning by organophosphorus compounds

F Worek, H Thiermann - Pharmacology & therapeutics, 2013 - Elsevier
Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem.
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …

[图书][B] Chemical warfare agents: chemistry, pharmacology, toxicology, and therapeutics

BJ Lukey, JA Romano Jr, JA Romano, H Salem… - 2007 - taylorfrancis.com
The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

[HTML][HTML] SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

L Gorecki, J Korabecny, K Musilek, D Malinak… - Archives of …, 2016 - Springer
Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

Improved multianalyte detection of organophosphates and carbamates with disposable multielectrode biosensors using recombinant mutants of Drosophila …

TT Bachmann, B Leca, F Vilatte, JL Marty… - Biosensors and …, 2000 - Elsevier
Engineered variants of Drosophila melanogaster acetylcholinesterase (AChE) were used as
biological receptors of AChE-multisensors for the simultaneous detection and discrimination …