In 2004, the US Food and Drug Administration (FDA) released an important report entitled
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …

ERBB receptors were linked to human cancer pathogenesis approximately three decades
ago. Biomedical investigators have since developed substantial understanding of the …

Purpose: While various studies have highlighted the prognostic significance of pathologic
complete response (pCR) after neoadjuvant chemotherapy (NAT), the impact of additional …

Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …

Background Approximately one‐fifth of women who develop early breast cancer have HER2‐
positive tumours, which if untreated, have a worse prognosis than HER2‐negative tumours …

The accidental discovery of the anticancer properties of cisplatin and its clinical introduction
in the 1970s represent a major landmark in the history of successful anticancer drugs …

Learning Objectives Contrast the current strengths and limitations of the three main slide-
based techniques (IHC, FISH, and CISH) currently in clinical use for testing breast cancer …

Purpose We evaluated whether patients with human epidermal growth factor receptor 2
(HER2)–positive primary breast tumors had metastatic tumors that were HER2 positive …

Background Inflammatory breast cancer (IBC) represents the most aggressive presentation
of breast cancer. Women diagnosed with IBC typically have a poorer prognosis compared …

Cisplatin is used for the treatment of many types of solid cancers. While testicular cancers
respond remarkably well to cisplatin, the therapeutic efficacy of cisplatin for other solid …