An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure
The charge of this Joint ATS/ERS Task Force was to critically review the state-of-the-art
stereological methods in lung morphometry, provide practical guidelines for use of these …
stereological methods in lung morphometry, provide practical guidelines for use of these …
Hyperpolarized gas MR Imaging of the lung: current status as a research tool
Hyperpolarized gas magnetic resonance imaging has been explored extensively as a
promising tool for the quantitative evaluation of regional pulmonary pathophysiology. This …
promising tool for the quantitative evaluation of regional pulmonary pathophysiology. This …
Amelioration of elastase‐induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice
Background and Purpose Chronic obstructive pulmonary disease, encompassing chronic
airway obstruction and lung emphysema, is a major worldwide health problem and a severe …
airway obstruction and lung emphysema, is a major worldwide health problem and a severe …
3He diffusion MRI in human lungs
JC Woods, MS Conradi - Journal of Magnetic Resonance, 2018 - Elsevier
Hyperpolarized 3 He gas allows the air spaces of the lungs to be imaged via MRI. Imaging of
restricted diffusion is addressed here, which allows the microstructure of the lung to be …
restricted diffusion is addressed here, which allows the microstructure of the lung to be …
Distribution of aerosolized particles in healthy and emphysematous rat lungs: Comparison between experimental and numerical studies
In silico models of airflow and particle deposition in the lungs are increasingly used to
determine the therapeutic or toxic effects of inhaled aerosols. While computational methods …
determine the therapeutic or toxic effects of inhaled aerosols. While computational methods …
Scale dependence of structure-function relationship in the emphysematous mouse lung
The purpose of this study was to determine how the initial distribution of elastase in mouse
lungs determines the time course of tissue destruction and how structural heterogeneity at …
lungs determines the time course of tissue destruction and how structural heterogeneity at …
Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice
In this work, we compare two methods for evaluating and quantifying pulmonary airspace
enlargement in a mouse model of chronic cigarette smoke exposure. Standard stereological …
enlargement in a mouse model of chronic cigarette smoke exposure. Standard stereological …
Noninvasive detection of pulmonary tissue destruction in a mouse model of emphysema using hyperpolarized 129Xe MRS under spontaneous respiration
H Imai, A Kimura, S Iguchi, Y Hori… - Magnetic …, 2010 - Wiley Online Library
In the present study, a chemical shift saturation recovery method in hyperpolarized 129Xe
MR spectroscopy measurements was applied to two groups of spontaneously breathing …
MR spectroscopy measurements was applied to two groups of spontaneously breathing …
Relaxation of hyperpolarized 129Xe in a deflating polymer bag
In magnetic resonance imaging with hyperpolarized (HP) noble gases, data is often
acquired during prolonged gas delivery from a storage reservoir. However, little is known …
acquired during prolonged gas delivery from a storage reservoir. However, little is known …
MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats
Aerosolized drugs are increasingly being used to treat chronic lung diseases or to deliver
therapeutics systemically through the lung. The influence of disease, such as emphysema …
therapeutics systemically through the lung. The influence of disease, such as emphysema …