A nomenclature consensus for nervous system organoids and assembloids
Self-organizing three-dimensional cellular models derived from human pluripotent stem
cells or primary tissue have great potential to provide insights into how the human nervous …
cells or primary tissue have great potential to provide insights into how the human nervous …
Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …
the mechanisms of which remain largely elusive. Recently, integration of technological …
Maturation and circuit integration of transplanted human cortical organoids
Self-organizing neural organoids represent a promising in vitro platform with which to model
human development and disease,,,–. However, organoids lack the connectivity that exists in …
human development and disease,,,–. However, organoids lack the connectivity that exists in …
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
Realizing the full utility of brain organoids to study human development requires
understanding whether organoids precisely replicate endogenous cellular and molecular …
understanding whether organoids precisely replicate endogenous cellular and molecular …
Spatially controlled construction of assembloids using bioprinting
The biofabrication of three-dimensional (3D) tissues that recapitulate organ-specific
architecture and function would benefit from temporal and spatial control of cell-cell …
architecture and function would benefit from temporal and spatial control of cell-cell …
Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes
Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …
Integrating organoids and organ-on-a-chip devices
Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids
Realizing the full potential of organoids and assembloids to model neural development and
disease will require improved methods for long-term, minimally invasive recording of …
disease will require improved methods for long-term, minimally invasive recording of …
Microglia-like cells promote neuronal functions in cerebral organoids
I Fagerlund, A Dougalis, A Shakirzyanova… - Cells, 2021 - mdpi.com
Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …
vitro research window to the development of the cerebral cortex. However, a key player in …
Human assembloids
S Kanton, SP Paşca - Development, 2022 - journals.biologists.com
Deconstructing and then reconstructing developmental processes ex vivo is crucial to
understanding how organs assemble and how physiology can be disrupted in disease …
understanding how organs assemble and how physiology can be disrupted in disease …