Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains.
Developing improved vaccines that elicit broader immunity remains a public health priority …

Antibody responses are essential for protection against influenza virus infection. Humans
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …

The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …

Influenza virus remains a threat because of its ability to evade vaccine-induced immune
responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a …

Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …

Germinal center (GC) B cells evolve toward increased affinity by a Darwinian process that
has been studied primarily in genetically restricted, hapten-specific responses. We explored …

R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA
replication and repair, chromatin and transcription regulation, as well as telomere …

Despite the biological importance of protein–protein complexes, determining their structures
and association mechanisms remains an outstanding challenge. Here, we report the results …

SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS)
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …

Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza
HA promotes viral entry by engaging the receptor and mediating virus–host membrane …