Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Gout is a crystal-deposition disease that results from chronic elevation of uric acid levels
above the saturation point for monosodium urate (MSU) crystal formation. Initial presentation …

The impact of sugar consumption on health continues to be a controversial topic. The
objective of this review is to discuss the evidence and lack of evidence that allows the …

A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …

Gout is well known as an inflammatory rheumatic disease presenting with arthritis and
abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic …

Genome-wide association studies that scan the genome for common genetic variants
associated with phenotype have greatly advanced medical knowledge. Hyperuricemia is no …

Gout is one of the most common inflammatory arthritides, caused by hyperuricemia, with an
increasing prevalence. Hyperuricemia is often a consequence of renal underexcretion of …

Objectives Twenty-eight genetic loci are associated with serum urate levels in Europeans.
Evidence for association with gout at most loci is absent, equivocal or not replicated. Our aim …

Background The prevalence of hyperuricemia and gout has increased in recent decades.
The role of dietary fructose in the development of these conditions remains unclear …

Background: Acute gouty arthritis (AGA) is the most common first symptom of gout, and the
development of gout as a metabolic and immune inflammatory disease is also correlated …