The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Hematopoiesis is the formation of blood cellular components and, consequently, immune
cells. In a more complete definition, this process refers to the formation, growth, maturation …

Hypoxia-inducible transcription factors (HIFs) are fundamental to cellular adaptation to low
oxygen levels, but it is unclear how they interact with chromatin and activate their target …

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and
hold promise for regenerative medicine. For understanding pluripotency and lineage …

Extramedullary hematopoiesis (EMH) is the expansion and differentiation of hematopoietic
stem and progenitor cells outside of the bone marrow. In postnatal life, as a compensatory …

Transcription must be tightly controlled to regulate gene expression and development.
However, our understanding of the molecular mechanisms that influence transcription and …

Abstract Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases play critical roles
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell proliferation …

The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4
(H3K4) methylation, a conserved trait of euchromatin associated with transcriptional …

Purpose Pathogenic variants in SETD1B have been associated with a syndromic
neurodevelopmental disorder including intellectual disability, language delay, and seizures …