The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Tea is one of the most widely consumed beverages worldwide, and is available in various
forms. Green tea is richer in antioxidants compared to other forms of tea. Tea is composed of …

Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …

Rationale: Obesity-associated cardiomyopathy characterized by hypertrophy and
mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy …

Diabetes mellitus has become a serious and growing public health concern. It has high
morbidity and mortality because of its complications, such as diabetic nephropathy, diabetic …

Doxorubicin (DOX)-induced cardiotoxicity has been a well-known phenomenon to clinicians
and scientists for decades; however, molecular mechanisms underlying DOX cardiotoxicity …

Proteasomal activity is compromised in diabetic hearts that contributes to proteotoxic
stresses and cardiac dysfunction. Osteocrin (OSTN) acts as a novel exercise-responsive …